Global & Disaster Medicine

5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin

CDC-EID

Abstract:  “The US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague.”

Apangu T, Griffith K, Abaru J, Candini G, Apio H, Okoth F, et al. Successful treatment of human plague with oral ciprofloxacin. Emerg Infect Dis. 2017 Mar [date cited]. http://dx.doi.org/10.3201/eid2303.161212

Demographic and clinical characteristics of 5 patients with culture-confirmed plague (Yersina pestis infection) who were treated successfully with oral ciprofloxacin, Uganda, 2011–2014

Patient no. Age, y/sex Length of illness, d* Symptoms Laboratory evidence Ciprofloxacin dose, mg†
1 10/F 7 Fever, left axillary bubo Bubo, blood cultures positive 250
2 52/F 4 Fever, right axillary bubo Bubo, blood cultures positive 650
3 27/F 1 Fever, left inguinal bubo Bubo, blood cultures positive 750
4 36/M 1 Fever, left axillary bubo Blood culture positive 625
5 13/M 6 Fever, chest pain, cough, blood-tinged sputum Sputum culture positive, blood culture negative 375

*At time treatment was sought.
†Orally, twice daily; ≈15 mg/kg bodyweight with a maximum of 750 mg.


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