Global & Disaster Medicine

Archive for December, 2018

Aspidosperma pyrifolium: Anti-malarial plant?

Malaria Journal

Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity

  • Isabela P. Ceravolo
  • Carlos L. Zani
  • Flávio J. B. Figueiredo
  • Markus Kohlhoff
  • Antônio E. G. Santana
  • Antoniana U. Krettli
Malaria Journal 2018; 17:436

https://doi.org/10.1186/s12936-018-2568-y

 


A Dual Vaccine against Anthrax and Plague

Pan Tao, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Jian Sha, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
“…..We engineered a virus nanoparticle vaccine using bacteriophage T4 by incorporating key antigens of both B. anthracis and Y. pestis into one formulation. Two doses of this vaccine provided complete protection against both inhalational anthrax and pneumonic plague in animal models. This dual anthrax-plague vaccine is a strong candidate for stockpiling against a potential bioterror attack involving either one or both of these biothreat agents. Further, our results establish the T4 nanoparticle as a novel platform to develop multivalent vaccines against pathogens of high public health significance……”
Plague ecology in the U.S. infographic.

A simple, rapid, and specific early detection of anthrax infection

PLOS

Suryadi K, Shine N (2018) Design and use of a novel substrate for simple, rapid, and specific early detection of anthrax infection. PLoS ONE 13(11): e0207084. https://doi.org/10.1371/journal.pone.0207084

“……Bacillus anthracis is a major biological warfare threat. The inhalation form of infection can kill quickly. While antibiotic treatment is effective, if diagnosis is delayed, the rapidly produced toxin may already be present in lethal amounts. This report describes a fast, sensitive, specific and accurate method for detection of active infection by Bacillus anthracis in plasma…..”

Slideshow image 1: The type of illness a person develops depends on how anthrax spores enter the body. All types of anthrax can cause death if they are not treated with antibiotics.

 

 

 


12/4/2012: Bopha, a Category 5 typhoon nicknamed “Pablo,” struck the Philippines and the flood waters destroyed entire villages and killed over 1000 people

History

https://www.youtube.com/watch?v=MmIXVIPu4Ws


Arkansas: One child was killed and at least 45 others were injured when a charter bus carrying a youth football team from Tennessee rolled off an interstate off-ramp and overturned.

CBS


How FDA helps make MCMs (medical countermeasures) available in emergencies

How FDA helps make MCMs available in emergencies
The first in an occasional series on the ways FDA helps prepare for and respond to public health emergencies
During public health emergencies, medical countermeasures (MCMs) may be needed to prevent or treat diseases or conditions caused by chemical, biological, radiological, or nuclear (CBRN) agents or emerging infectious diseases, like pandemic influenza or Ebola.
Depending on the emergency and public health need, MCMs may be provided by the Strategic National Stockpile (managed by the Office of the Assistant Secretary for Preparedness and Response (ASPR), in the U.S. Department of Health and Human Services (HHS)), or through state and local stockpiles or other supplies. When needed during a public health emergency, MCMs are usually dispensed or administered to impacted individuals by healthcare workers and public health responders under official federal, state, and local emergency response plans.
In some cases, MCMs might already be approved and will be used in approved ways during a response. In other cases, the best medical products available for a response might be unapproved or need to be used in unapproved ways. Because of our role in regulating medical products, FDA may need to use special authorities to allow the use of such MCMs in impacted populations during or in anticipation of emergencies.
 
Mechanisms FDA can use to allow the emergency use of MCMs include the Emergency Use Authorization (EUA) authority and several authorities related to the emergency use of approved MCMs.

CDC reports 18 more cases of the mysterious AFM in the week ending on Nov 30, bringing this year’s total to 134 cases confirmed in 33 states, among 299 cases reported, and the agency says the outbreak “appears to have peaked.”

States with confirmed cases of AFM, 2018 (N=116)

 


DRC Ebola total climbs to 444 with cases

DRC

SITUATION ÉPIDÉMIOLOGIQUE DANS LES PROVINCES DU NORD-KIVU ET DE L’ITURI

Lundi 3 décembre 2018

La situation épidémiologique de la Maladie à Virus Ebola en date du 2 décembre 2018 :
  • Depuis le début de l’épidémie, le cumul des cas est de 444, dont 396 confirmés et 48 probables. Au total, il y a eu 260 décès (212 confirmés et 48 probables) et 140 personnes guéries.
  • 72 cas suspects en cours d’investigation.
  • 4 nouveaux cas confirmés, dont 2 à Beni, 1 à Katwa et 1 à Kalunguta.
  • 5 nouveaux décès de cas confirmés, dont 3 à Beni, 1 à Butembo et 1 à Kalunguta.
  • 1 nouvelle personne guérie sortie du CTE de Butembo.

A “dramatic increase” in sexual violence occurred in late November, as about 125 women and girls walking to a food distribution site in Bentiu were “raped, whipped and clubbed.”

NYT


In the aftermath of Stoneman Parker, consequences for those who could’ve helped but didn’t.

NY Daily News

“……an 18-year veteran of the department, arrived at the school
three and a half minutes after Nikolas Cruz began shooting. With 17 people
already shot and 17 more already dead, Eason instead spent two minutes
driving to the opposite side of campus to put on his bulletproof vest and
fidgeting with his body camera……Capt. Jan Jordan resigned and Sgt. Brian Miller was
placed on restricted duty for the department’s failure to respond properly
to the Parkland shooting.

Four Stoneman Douglas employees – assistant principals Jeff Morford, Winfred
Porter Jr., and Denise Reed and security specialist Kelvin Greenleaf – were
reassigned pending investigations last week.

School resource officer Scot Peterson, who took cover outside the school
until the shooting was over, resigned in disgrace………”


Categories

Recent Posts

Archives

Admin