Global & Disaster Medicine

Japanese researchers described two H3N2 flu viruses with mutations that may increase resistance to the new flu antiviral baloxavir marboxil (Xofluza)

Takashita Emi, Kawakami Chiharu, Morita Hiroko, Ogawa Rie, Fujisaki Seiichiro, Shirakura Masayuki, Miura Hideka, Nakamura Kazuya, Kishida Noriko, Kuwahara Tomoko, Mitamura Keiko, Abe Takashi, Ichikawa Masataka, Yamazaki Masahiko, Watanabe Shinji, Odagiri Takato, on behalf of the Influenza Virus Surveillance Group of Japan. Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018. Euro Surveill. 2019;24(3):pii=1800698. https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800698

Gubareva Larisa V, Mishin Vasiliy P, Patel Mira C, Chesnokov Anton, Nguyen Ha T, De La Cruz Juan , Spencer Sarah, Campbell Angela P, Sinner Mallory, Reid Heather, Garten Rebecca, Katz Jackie M, Fry Alicia M, Barnes John, Wentworth David E. Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons. Euro Surveill. 2019;24(3):pii=1800666. https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800666

Figure 1. Influenza Virus Features

 


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