Global & Disaster Medicine

Archive for November, 2019

Weather in and around the USA and beyond

National Weather Outlook

Central Great Lakes sector loop

Northeast sector loop


Thelaziasis image gallery

Thelazia spp. adults.Adults of Thelazia spp. reside in the conjunctival sac of their definitive hosts, which are usually dogs or other canids, cattle, and horses; humans are usually only incidental hosts. Adults measure up to 2.1 cm in length. Thelazia species may be differentiated by the appearance of the cuticular striations, the depth and width of the buccal cavity, the placement of the vulval opening relative to the esophago-intestinal junction and the morphology of the tail and anal opening.

Thelazia californiensis

Figure A: Anterior end of a female <em>Thelazia californiensis</em> showing small, shallow, buccal cavity (arrow) and prominent widely spaced cuticular striations.

Figure A: Anterior end of a female Thelazia californiensis showing small, shallow, buccal cavity (arrow) and prominent widely spaced cuticular striations.

Figure B: Mid-section of a female <em>Thelazia californiensis</em>. Note the prominent, widely spaced, and serrate cuticular striations.

Figure B: Mid-section of a female Thelazia californiensis. Note the prominent, widely spaced, and serrate cuticular striations.

Figure C: Posterior end of a female <em>Thelazia californiensis</em> with protruding anal opening and phasmids.

Figure C: Posterior end of a female Thelazia californiensis with protruding anal opening and phasmids.
Thelazia callipaeda

Figure A

Figure A: Adult male and female Thelazia callipaeda.

Figure B: Anterior of Thelazia callipaeda showing wide, moderate depth, buccal cavity and prominent tightly spaced cuticular striations.

Figure B: Anterior of Thelazia callipaeda showing wide, moderate depth, buccal cavity and prominent tightly spaced cuticular striations.

• Figure C: Anterior of Thelazia callipaeda female showing vulval opening (arrow), which is protruded, anterior to esophageal-intestinal junction (dart).

Figure C: Anterior of Thelazia callipaeda female showing vulval opening (arrow), which is protruded, anterior to esophageal-intestinal junction (dart).

Figure D: Mid-section of adult female Thelazia callipaeda showing live larvae in utero

Figure D: Mid-section of adult female Thelazia callipaeda showing live larvae in utero

Figure E: Posterior of adult male Thelazia callipaeda showing spicules (Nomarsky phase contrast).

Figure E: Posterior of adult male Thelazia callipaeda showing spicules (Nomarsky phase contrast).

Figure F: Posterior of adult female Thelazia callipaeda showing anal opening (Nomarsky phase contrast)

Figure F: Posterior of adult female Thelazia callipaeda showing anal opening (Nomarsky phase contrast)
Thelazia gulosa

thelaziasis image

Figure A: Adult female Thelazia gulosa removed from the surface of the eye of a human, showing intestine and egg-filled ovaries taking up the majority of the length of the body.

thelaziasis image

Figure B: Adult female Thelazia gulosa immediately after removal from the eye. Image courtesy of Oregon Health & Science University, Department of Pathology.

Thelaziasis

Figure C: Anterior of Thelazia gulosa showing buccal cavity, cuticular ridges, and esophageal-intestinal junction.

thelaziasis image

Figure D: Deep, cup-like buccal cavity and widely spaced, moderately distinct cuticular striations of Thelazia gulosa.

thelaziasis image

Figure E: Esophageal-intestinal junction of Thelazia gulosa.

thelaziasis image

Figure F: Non-protruding vulval opening (circle) of Thelazia gulosa almost at the same level as the esophageal-intestinal junction.

thelaziasis image

Figure G: Mid-body of Thelazia gulosa with prominent cuticular striations, intestinal tube, and ovaries containing spirurid eggs.

thelaziasis image

Figure H: Tail of female Thelazia gulosa with non-protruding anal opening and post-anal papilla.

thelaziasis images

Figure I: Adult Thelazia gulosa removed from the eye of a human, resting on a person’s finger.
arvae of Thelazia spp

Figure A: L1 larva of Thelazia sp., likely T. callipaeda based on the patient’s travel history. L1 larvae measure up to 400 µm long and 13.5 µm wide. While not visible on this specimen, normally larvae are passed encased in a shell membrane.

Figure A: L1 larva of Thelazia sp., likely T. callipaeda based on the patient’s travel history. L1 larvae measure up to 400 µm long and 13.5 µm wide. While not visible on this specimen, larvae are normally passed encased in a shell membrane.

Figure B: Anterior end of the larva. Note the lack of buccal cavity, and the developing cuticular striations.

Figure B: Anterior end of the larva in Figure B. Note the lack of buccal cavity, and the developing cuticular striations.
Intermediate hosts of Thelazia spp.

Fannia canicularis

Figure A: Fannia canicularis, the lesser house fly. This species, as well as Fannia benjamini, is considered the primary vector of T. californiensis in the United States. Image courtesy of Joyce Gross.

Phortica variegata, Thelazia callipaeda

Figure B: Male (left) and female (right) Phortica variegata, the variegated fruit fly. This species is the main vector of Thelazia callipaeda in Europe and Asia. Image courtesy of Dr. Thomas Werner, Ph.D., Department of Biological Sciences, Michigan Technological University.

Musca autumnalis, T. gulosa

Figure C: Female Musca autumnalis, the autumn house fly. This species is the primary vector of T. gulosa in the United States and in Europe. Image courtesy of Joyce Gross.

Human H9N2 infections have been reported only in Hong Kong, China, Bangladesh, and Pakistan. Now it’s in India!

Potdar V, Hinge D, Satav A, Simões EF, Yadav PD, Chadha MS. Laboratory-confirmed avian influenza A(H9N2) virus infection, India, 2019. Emerg Infect Dis. 2019 Dec [date cited]. https://doi.org/10.3201/eid2512.190636

Abstract

“A 17-month-old boy in India with severe acute respiratory infection was laboratory confirmed to have avian influenza A(H9N2) virus infection. Complete genome analysis of the strain indicated a mixed lineage of G1 and H732. The strain also was found to be susceptible to adamantanes and neuraminidase inhibitors.”

Phylogenetic tree of hemagglutinin gene (A) and neuraminidase gene (B) gene of influenza virus A/India/TCM 2581/2019(H9N2) from India (black circle) and reference strains. The numbers above the branches are the bootstrap probabilities (%) for each branch, determined by using the MEGA 7.0 (https://megasoftware.net). Human cases from other countries are in bold. Scale bars indicate substitutions per site.

The case:  “……The child, a resident of Melghat, had fever, cough, breathlessness, and difficulty feeding for 2 days since illness onset on January 31, 2019. His high intermittent grade fever had no diurnal variation and no association with rash or mucocutaneous lesions. Examination revealed a conscious, restless child with a respiratory rate of 48 breaths/min and lower chest wall in-drawing with intermittent absence of breathing for >20 seconds. He was fully immunized for his age, with bacillus Calmette–Guérin, diphtheria, hepatitis B, poliovirus, and measles vaccines. Both length and weight for age were less than −3 SD. History of travel with his parents to a local religious gathering 1 week before symptom onset was elicited. The father had similar symptoms on return from the gathering but could not undergo serologic testing because of his migrant work. No history of poultry exposure was elicited. The child received an antibacterial drug and antipyretics and recovered uneventfully.….”


The Philippine Department of Health (DOH) has confirmed a fourth polio case in the country

Xinhua

“……Until Sep 19, the Philippines had been polio-free for 19 years. The previous cases have been in children under the age of 5 and classified as poliovirus type 2.

Following the first case detection, the government launched a nationwide polio vaccine campaign, and health officials said that, as of Oct 31 more than 95% of children 0 to 59 months old have been vaccinated against the virus…….”


NASA: Tropical Cyclone Maha

Spate of Cyclones in the North Indian Ocean

Tropical Cyclone Maha has taken a sharp turn over the Arabian Sea and is now poised to brush India’s west coast on November 7, 2019. By landfall, forecasters expect the storm to have weakened from its extremely severe peak on November 4, which was when the Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA’s Terra satellite acquired this natural-color image. At the time, sustained winds measured 185 kilometers (115 miles) per hour—the equivalent of a category 3 storm on the Saffir-Simpson wind scale.

Considered in isolation, there’s nothing particularly unusual about Maha. However, in the context of the season and the basin, it is the latest in a series of strong tropical cyclones in an area that typically doesn’t see many. In fact, the North Indian basin is usually the least active in the Northern Hemisphere.


NASA: Haze Smothers Northern India

Haze Smothers Northern India


TAK-003: A new vaccine to prevent dengue may be on the horizon.

NPR

Green banner with images of mosquitoes feeding on host

“….The World Health Organization this year listed dengue as one of the top 10 threats to global health.

The mosquito-borne disease is a growing threat for several reasons. First, the sheer number of dengue cases has been increasing dramatically in recent years. The WHO says there’s been a 30-fold increase in infections since 1970. Last year nearly 100 million people came down with the disease, also known as breakbone fever.

Second, there’s no specific treatment for the viral disease. When outbreaks occur, local clinics can get overwhelmed with patients experiencing severe flu-like symptoms. Third, the disease is moving in to new areas as the mosquitoes that carry the dengue virus expand their range……results just published in the New England Journal of Medicine……. found TAK-003 to be 80% effective in preventing participants from getting dengue and 95% effective in preventing cases of severe dengue………The Takeda dengue vaccine still needs to win regulatory approval before it’s made available to the public. Company officials, however, are confident they’ll get it. This week Takeda opened a 100 million-euro factory in Germany exclusively to manufacture TAK-003……..”

Map of the United States showing  Laboratory-positive travel-associated and locally-acquired dengue cases. See table below.

States and territories reporting dengue cases – United States, 2019 (as of October 2, 2019)

 

 


All about chars…..

NPR

“……Chars are low-lying, temporary sand islands that are continuously formed and destroyed through silt deposition and erosion. They’re home to over six million people, who face repeated displacement from flooding and erosion — which may be getting worse because of climate change — and a range of health risks, including malnutrition, malaria, chronic diarrhea and other water-borne diseases.…..”


MERS-CoV in Pakistan

ABSTRACT:   ”  A high percentage of camel handlers in Saudi Arabia are seropositive for Middle East respiratory syndrome coronavirus. We found that 12/100 camel handlers and their family members in Pakistan, a country with extensive camel MERS-CoV infection, were seropositive, indicating that MERS-CoV infection of these populations extends beyond the Arabian Peninsula.

Zheng J, Hassan S, Alagaili AN, Alshukairi AN, Amor NMS, Mukhtar N, et al. Middle East respiratory syndrome coronavirus seropositivity in camel handlers and their families, Pakistan. Emerg Infect Dis. 2019 Dec [date cited]. https://doi.org/10.3201/eid2512.191169


WHO: In the past week, from 28 October to 3 November 2019, 10 new confirmed Ebola virus disease (EVD) cases were reported from five health zones in two affected provinces in the Democratic Republic of the Congo.

WHO

“…….As of 3 November 2019, a total of 3274 EVD cases were reported, including 3157 confirmed and 117 probable cases, of which 2185 cases died (overall case fatality ratio 67%). Of the total confirmed and probable cases, 56% (1843) were female, 28% (927) were children aged less than 18 years, and 5% (163) were healthcare workers. ……..”


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