Archive for the ‘Ebola’ Category
The UN Security Council passes a resolution demanding that all armed rebel groups in Ebola outbreak zones respect international law.
Thursday, November 1st, 2018Adopting Resolution 2439 (2018), Security Council Condemns Attacks by Armed Groups in Democratic Republic of Congo Jeopardizing Response to Ebola Outbreak
The Security Council today adopted a resolution condemning attacks by armed groups in the Democratic Republic of the Congo and their role in exacerbating the country’s ongoing Ebola outbreak, while demanding full, safe, immediate and unhindered access for the humanitarian and medical personnel working to save lives and prevent the virus from spreading across the region.
Adopting resolution 2439 (2018) by consensus, the Council reiterated its deep concern about the Democratic Republic of the Congo’s overall security and humanitarian situation, noting that both are exacerbated by the destabilizing activities of foreign and domestic armed groups. Recalling that the country’s Government bears the primary responsibility to protect civilians within its territory — including from crimes against humanity and war crimes — it expressed further concern about the security situation in areas affected by the recent Ebola outbreak and called for the immediate cessation of hostilities by all armed groups, including the Allied Democratic Forces (ADF).
Condemning in the strongest terms all attacks by armed groups — including those posing serious security risks for responders and jeopardizing the response to the Ebola outbreak — the Council demanded that all parties fully respect international law and ensure full, safe, immediate and unhindered access for humanitarian and medical personnel, as well as their equipment, transport and supplies.
By other terms of the text, the Council stressed the need for the international community to remain engaged in the strengthening of national health systems in line with the needs of the Government of the Democratic Republic of the Congo, noting that such efforts are instrumental in preventing a deterioration of the present crisis or addressing a future recurrence. It also emphasized the need for the Government, along with all relevant actors, to enhance efforts to implement — and communicate to the public — the established safety and health protocols and preventive measures to mitigate misinformation and undue alarm about the transmission and extent of the outbreak.
In addition, the Council took note of the World Health Organization’s (WHO) latest risk assessment regarding regional spread, expressing concern about the potential for the virus to expand to Uganda, Rwanda, South Sudan and Burundi. In that regard, it encouraged the Governments of those countries to continue efforts to prepare for operational readiness and emphasized the importance of maintaining flexible international support — financial, technical and in-kind — to bring the Ebola outbreak successfully under control.
Speaking following the adoption, Taye Atske Selassie (Ethiopia), one of the resolution’s two main co‑sponsors along with Sweden, noted that negotiations on the text were sparked by two recent briefings to the Council from the WHO Director‑General. Commending the leadership of the Government of the Democratic Republic of the Congo in responding to the Ebola outbreak, he declared: “Humanitarian actors are operating under enormous difficulties to save lives.” Today’s resolution underscores the need to address the security risks that are complicating those critical efforts even further. Welcoming concerted efforts by WHO and the United Nations Organization Stabilization Mission in the Democratic Republic of the Congo (MONUSCO), he said that while the former has decided that a “public health emergency of international concern” should not be declared at this time, officials remain deeply concerned and have called for intensified and ongoing vigilance.
Carl Skau (Sweden) said the text sends a clear message to all those involved in front‑line response efforts in the Democratic Republic of the Congo and neighbouring countries. Emphasizing that those working to save lives on the ground must never become targets themselves, he noted that the text commends the continued leadership of the WHO and other relevant actors and aims to remind all stakeholders of the importance of strengthening national health systems. In addition, it calls for full, safe and unhindered humanitarian access and accelerating funding to combat the outbreak. Noting that Sweden intends to provide additional funding to those efforts, he asked other Member States to consider doing the same, emphasizing that the Democratic Republic of the Congo stands at a pivotal moment in its history.
The meeting began at 10 a.m. and ended at 10:10 a.m.
Resolution
The full text of resolution 2439 (2018) reads as follows:
“The Security Council,
“Expressing grave concern about the most recent outbreak of the Ebola virus in the Democratic Republic of the Congo and the fact that this epidemic is occurring in the context of much wider humanitarian needs, in a country whose people have suffered from the recurrence of the disease, armed conflict and violence for the last few decades,
“Recognizing the recurring threat of the Ebola virus in the region since it was first discovered in 1976 and recalling its Resolution 2177 (2014) concerning the 2014 Ebola virus outbreak in West Africa,
“Recalling its determination in resolution 2409 (2018) that the situation in the Democratic Republic of the Congo continues to constitute a threat to international peace and security in the region, and expressing concern that this security situation negatively impacts the ability to respond to and contain the outbreak of the Ebola virus,
“Reaffirming its strong commitment to the sovereignty, independence, unity and territorial integrity of the Democratic Republic of the Congo and all States in the region, and emphasizing the need for cooperation and coordination with the Democratic Republic of the Congo to address the Ebola situation, as well as with the States in the region, as appropriate,
“Noting the reports presented to the Security Council on 28 August and on 3 October 2018 by the Director‑General of the World Health Organization (WHO),
“Commending the Government of the Democratic Republic of the Congo for its leadership in responding to the Ebola outbreak, particularly for providing free health care in affected health zones, as well as for its daily reporting on the status of the outbreak,
“Expressing appreciation for the efforts of all humanitarian and health workers on the ground, including WHO and its partners in the Global Outbreak Alert and Response Network, as well as all other front-line actors involved in the response effort,
“Commending the United Nations Organization Stabilization Mission in the Democratic Republic of the Congo (MONUSCO) for providing support to the efforts of the government of the Democratic Republic of the Congo, WHO and other actors to respond to the Ebola outbreak in an extremely challenging and dangerous environment,
“Underscoring the need to address the security situation in the areas affected by the disease and condemning all attacks against civilians,
“Expressing outrage and condemning in the strongest terms the recent attacks and the killings of two Congolese health workers attached to a Congolese army unit helping to combat the Ebola outbreak in the Democratic Republic of the Congo,
“Recalling resolution 2286 (2016) and urging all parties to the armed conflict to ensure full, safe, immediate and unhindered access for humanitarian personnel and medical personnel, to patients and others in need; condemning acts of violence, attacks and threats intentionally directed against medical personnel and humanitarian personnel exclusively engaged in medical duties, their means of transport and equipment, as well as hospitals and other medical facilities, exclusively fulfilling a medical or humanitarian function, as a violation of international humanitarian law; and deploring the long‑term consequences of such attacks for the civilian population and the health-care system of the Democratic Republic of the Congo,
“Recalling the International Health Regulations (2005), which are contributing to global public health security by improving the capacity of all countries to detect, assess, notify and respond to public health threats, underscoring the importance of abiding by these commitments and urging Member States to follow the advice of the WHO Director‑General regarding the current Ebola outbreak,
“Taking note of the cross‑border meeting among east African countries held in Entebbe, Uganda, on 3 October 2018, which reviewed the implementation of cross-border disease surveillance activities and the status of emergency preparedness activities in districts that border the Democratic Republic of the Congo and the East African Community; noting the need for awareness creation among district leaders in their roles in implementing the International Health Regulations (2005), and drawing attention to large‑scale population displacements in the region that could contribute to further spread of the Ebola virus,
“Underscoring that the control of outbreaks of major infectious diseases requires urgent action and greater national, regional and international collaboration and, in this regard, stressing the crucial and continued need for a WHO coordinated international response in the Democratic Republic of the Congo in collaboration with the Government,
“Commending Member States and multilateral organizations that have provided crucial assistance, including financial commitments, technical support and in-kind donations, to support the scaling up of emergency efforts to contain the Ebola outbreak and interrupt transmission of the virus, including by providing flexible funds to relevant United Nations agencies and international organizations, facilitating a more rapid and effective response and enabling them and national governments to purchase supplies and enhance emergency operations in the Democratic Republic of the Congo and neighbouring countries, as well as by collaborating with public and private sector partners to accelerate development of therapeutics, vaccines and diagnostics to treat patients and limit or prevent further infection or transmission,
“Welcoming the efforts of the African Union (AU), through the Africa Centre for Disease Control and Prevention (Africa CDC) in providing support to the government of the Democratic Republic of the Congo, WHO and its partners through a united, comprehensive and collective response to the outbreak, including through the deployment of healthcare workers to the eastern part of the Democratic Republic of the Congo,
“Emphasizing the role of all relevant United Nations System entities in supporting the national, regional and international efforts to respond to the Ebola outbreak, and recognizing in this regard the leading role of WHO,
“Taking note of the WHO protocols to prevent the transmission of the Ebola virus disease between individuals, organizations and populations, and underlining that the Ebola outbreak can be contained, including through the implementation of established safety and health protocols and other preventive measures that have proven effective,
“1. Reiterates its deep concern regarding the overall security and humanitarian situation in the Democratic Republic of the Congo, exacerbated by destabilizing activities of foreign and domestic armed groups, recalls the strategic importance of the implementation of the Peace, Security and Cooperation (PSC) Framework for the Democratic Republic of the Congo and the region, and reiterates its call to all signatories to fulfil their respective commitments under this Framework in order to address the root causes of conflict and put an end to recurring cycles of violence, and promote lasting regional development;
“2. Encourages the government of the Democratic Republic of the Congo, WHO, and other Ebola responders to continue to improve the transparency and accuracy of the daily reporting on the status of the outbreak;
“3. Recalls that the Government of the Democratic Republic of the Congo bears the primary responsibility to protect civilians within its territory and subject to its jurisdiction, including protection from crimes against humanity and war crimes;
“4. Expresses serious concern regarding the security situation in the areas affected by the Ebola outbreak, which is severely hampering the response efforts and facilitating the spread of the virus in the Democratic Republic of the Congo and the wider region; and calls for immediate cessation of hostilities by all armed groups, including the Allied Democratic Forces (ADF);
“5. Condemns in the strongest terms all attacks by armed groups, including those posing serious security risks for responders and jeopardizing the response to the Ebola outbreak;
“6. Demands that all parties to the armed conflict fully respect international law, including, as applicable, international human rights law and international humanitarian law, including their obligations under the Geneva Conventions of 1949 and the obligations applicable to them under the Additional Protocols thereto of 1977 and 2005, and further demands that all parties ensure full, safe, immediate and unhindered access for humanitarian and medical personnel, and their equipment, transport and supplies to the affected areas, and to respect and protect all civilians, including those in the region who are at risk of Ebola, and humanitarian and health workers; stresses that humanitarian response teams and hospitals and other medical facilities providing life-saving assistance and relief to those in need must be respected and protected, and that they must not be a target, in accordance with international law;
“7. Notes the important positive role of MONUSCO, within its existing mandate, in supporting the efforts of the government of the Democratic Republic of the Congo, WHO and other actors to bring the Ebola outbreak successfully under control and in ensuring, within its area of operations, effective protection of civilians;
“8. Emphasizes the need for the Government of the Democratic Republic of the Congo, and all relevant actors providing assistance in response to the Ebola outbreak, to enhance efforts to communicate to the public, as well as to implement, the established safety and health protocols and preventive measures to mitigate against misinformation and undue alarm about the transmission and extent of the outbreak among and between individuals and communities; underscores the need to enhance community engagement working closely with religious leaders, youth and women’s groups and with the families themselves, including in the context of resumed humanitarian assistance efforts;
“9. Emphasizes that men and women are affected differently by the Ebola outbreak and underlines that a gender‑sensitive response that addresses the specific needs of both men and women is required, and stresses the importance of the full, active and meaningful engagement of women in the development of such responses;
“10. Stresses the need for continuous and improved surveillance of those who have been in contact with infected people as well as the need for following up with Ebola survivors, ensuring they are clinically monitored to prevent any delayed clinical manifestations and the risk of sexual transmission of Ebola; underlines the need to provide Ebola survivors with psychological and social support to help them face and overcome possible stigmatization;
“11. Takes note of WHO’s latest assessment of the risk of regional spread and expresses great concern about the potential for the virus to spread into Uganda, Rwanda, South Sudan and Burundi and encourages those governments to continue efforts to prepare for operational readiness, in full cooperation with WHO;
“12. Emphasizes the importance of maintaining international support and engagement — financially, technically and in-kind — to bring the Ebola outbreak successfully under control; stresses in this context the importance of flexible financial support for the response efforts, enabling a more rapid and effective response, also expresses concern that the overall humanitarian appeal for the Democratic Republic of the Congo remains severely underfunded;
“13. Encourages the Government of the Democratic Republic of the Congo and countries of the region to continue efforts to address and resolve the wider political, security, socioeconomic and humanitarian consequences of the Ebola outbreak, as well as to provide sustainable and responsive public health mechanisms;
“14. Requests all relevant parts of the United Nations System to accelerate their response to the Ebola outbreak, within the overall coordination of WHO, including by supporting the development and implementation of preparedness and operational plans and liaison and collaboration with governments of the region and those providing assistance;
“15. Stresses the need for the international community to remain engaged in supporting the strengthening of national health systems, in line with the needs of the government of the Democratic Republic of the Congo, which are instrumental in preventing a deterioration of the present crisis or addressing a future recurrence;
“16. Welcomes action and results of the WHO Health Emergencies Programme and encourages WHO and the whole United Nations system to build on and benefit from the lessons learned from the Ebola virus outbreak in West Africa in 2014, and to continue to further strengthen its technical leadership and operational support, monitor Ebola transmission, assist in identifying existing response needs and partners to meet those needs to facilitate the availability of essential data and hasten the development and implementation of therapies and vaccines according to best clinical and ethical practices;
“17. Decides to remain seized of the matter.”
UK Researchers: The immune response from three Ebola vaccines, including VSV-EBOV, lasts at least 2.5 years.
Thursday, November 1st, 2018Durability of immune responses induced by three leading candidate Ebola vaccine regimes; rVSV ZEBOV, ChAd3 EBO Z-MVA BN-Filo and AdHu26.ZEBOV-MVA BN Filo
October 29, 2018, 4:30 PM – 4:45 PM | Sheraton – Grand Ballroom A/B (5th Floor) |
- Authors
- Katie J. Ewer1, Catherine Smith2, Esha Sarkar2, Georgina Bowyer1, Thomas Rampling1, Catherine Mair1, Duncan Bellamy1, Suleman Sabir3, Christopher Davies3, Navin Venkatraman1, Rebecca Conway-Jones1, Danielle Campbell2, Charlotte Boyer2, Adrian V. Hill1, Emma Thomson3, Matthew D. Snape2
1The Jenner Institute, University of Oxford, Oxford, United Kingdom, 2Oxford Vaccine Group, University of Oxford, Oxford, United Kingdom, 3MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom
“Of the vaccines developed in response to the 2014-16 Ebola outbreak in West Africa, three which encoded the Zaire Ebola glycoprotein, showed acceptable reactogenicity and promising immunogenicity in early-stage clinical trials – a single-dose approach based on a replicating vesicular-stomatitis virus (rVSV ZEBOV) and two heterologous prime-boost combinations using replication-deficient adenoviruses (ChAd3 and AdHu26) to prime and the multivalent MVA BN-Filo to boost. The rVSV ZEBOV vaccine showed 100% vaccine efficacy in a phase III ring vaccination trial in the short-term following exposure to Ebola virus disease (EVD) cases. However, durability of protective efficacy has not been assessed. Clinical trials were undertaken in Oxford of both prime-boost regimes and volunteers have been followed up to determine durability of both humoral and cellular immunity. This revealed that 91% of 43 recipients of AdHu26/MVA vector vaccine recipients had positive glycoprotein specific IgG titres at 2.5 years post immunisation, as did 54% of 13 recipients of Chad3/MVA vectored vaccines. Furthermore, in October 2015, rVSV ZEBOV was administered to 26 contacts of a UK health-care worker who had become infected with EVD in Sierra Leone, recovered and then subsequently relapsed. Using samples from this cohort, we will be able to undertake for the first time comparative immunogenicity measurements using a standardised ELISA and validated ELISPOT assay to determine humoral and cellular immunity against the Zaire ebolavirus glycoprotein induced by these three vaccine regimes. Samples taken 2.5 years post-vaccination will be compared to determine whether differences in quality, quantity and persistence of immunity are observed. These data are important for long-term strategic planning for prophylactic protection of front-line healthcare workers in regions at risk of future outbreaks.
Ebola Virus Outbreaks by Species and Size, Since 1976
Tuesday, October 30th, 2018aire ebolavirus, Bundibugyo ebolavirus, and Sudan ebolavirus are the three species of Ebola virus responsible for the larger outbreaks in Africa. Zaire ebolavirus, the most fatal Ebola virus, was associated with the 2014-2016 outbreak in West Africa, the largest Ebola outbreak to date with more than 28,600 cases. Other large outbreaks of Zaire ebolavirus have resulted in hundreds of cases in the Democratic Republic of the Congo (DRC) and Gabon. Smaller outbreaks of this species have also occurred in DRC and Gabon, as well as the Republic of the Congo and South Africa. Sudan ebolavirus, with a fatality rate of 50 percent, has been the cause of several outbreaks in Uganda and others near the border between South Sudan and DRC. Bundibugyo ebolavirus, discovered in 2007, was associated with two outbreaks, one in DRC and the other on the border of DRC and Uganda. Taï Forest ebolavirus, the only other Ebola virus found in West Africa to date, was the cause of one case identified in Côte d’Ivoire.
Country | Town | Cases | Deaths | Species | Year |
---|---|---|---|---|---|
Dem. Rep. of Congo | Bikoro | ongoing | ongoing | Zaire ebolavirus | 2018 |
Dem. Rep. of Congo | Likati | 8 | 4 | Zaire ebolavirus | 2017 |
Dem. Rep. of Congo | multiple | 66 | 49 | Zaire ebolavirus | 2014 |
Multiple countries(https://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/distribution-map.html#areas) | multiple | 28652 | 11325 | Zaire ebolavirus | 2014-2016 |
Uganda | Luwero District | 6* | 3* | Sudan ebolavirus | 2012 |
Dem. Rep. of Congo | Isiro Health Zone | 36* | 13* | Bundibugyo ebolavirus | 2012 |
Uganda | Kibaale District | 11* | 4* | Sudan ebolavirus | 2012 |
Uganda | Luwero District | 1 | 1 | Sudan ebolavirus | 2011 |
Dem. Rep. of Congo | Luebo | 32 | 15 | Zaire ebolavirus | 2008 |
Uganda | Bundibugyo | 149 | 37 | Bundibugyo ebolavirus | 2007 |
Dem. Rep. of Congo | Luebo | 264 | 187 | Zaire ebolavirus | 2007 |
South Sudan | Yambio | 17 | 7 | Sudan ebolavirus | 2004 |
Republic of Congo | Mbomo | 35 | 29 | Zaire ebolavirus | 2003 |
Republic of Congo | Mbomo | 143 | 128 | Zaire ebolavirus | 2002 |
Republic of Congo | Not specified | 57 | 43 | Zaire ebolavirus | 2001 |
Gabon | Libreville | 65 | 53 | Zaire ebolavirus | 2001 |
Uganda | Gulu | 425 | 224 | Sudan ebolavirus | 2000 |
South Africa | Johannesburg | 2 | 1 | Zaire ebolavirus | 1996 |
Gabon | Booue | 60 | 45 | Zaire ebolavirus | 1996 |
Gabon | Mayibout | 37 | 21 | Zaire ebolavirus | 1996 |
Dem. Rep. of Congo | Kikwit | 315 | 250 | Zaire ebolavirus | 1995 |
Côte d’Ivoire (Ivory Coast) | Tai Forest | 1 | 0 | Taï Forest ebolavirus | 1994 |
Gabon | Mekouka | 52 | 31 | Zaire ebolavirus | 1994 |
South Sudan | Nzara | 34 | 22 | Sudan ebolavirus | 1979 |
Dem. Rep. of Congo | Tandala | 1 | 1 | Zaire ebolavirus | 1977 |
South Sudan | Nzara | 284 | 151 | Sudan ebolavirus | 1976 |
Dem. Rep. of Congo | Yambuku | 318 | 280 | Zaire ebolavirus | 1976 |
*Numbers reflect laboratory confirmed cases only.
17 more cases of Ebola and 10 more deaths in the ongoing outbreak in the far eastern reaches of the Democratic Republic of the Congo (DRC).
Tuesday, October 30th, 2018SITUATION ÉPIDÉMIOLOGIQUE DANS LES PROVINCES DU NORD-KIVU ET DE L’ITURI
Lundi 29 octobre 2018
- Au total, 274 cas de fièvre hémorragique ont été signalés dans la région, dont 239 confirmés et 35 probables.
- Sur les 239 confirmés, 139 sont décédés et 73 sont guéris . Les autres sont hospitalisés dans les différents Centre de Traitement d’Ebola (CTE) installés.
- 32 cas suspects en cours d’investigation.
- 7 nouveaux cas confirmés, dont 4 à Beni et 3 à Butembo.
- 4 nouveaux décès de cas confirmés, dont 3 à Beni et 1 à Butembo.
- 3 nouveaux guéris, dont 2 à Butembo et 1 à Beni.
- 5.991 contacts à suivre à ce jour.
New violence in the DRC threatens to again force the suspension of crucial EBV containment efforts.
Monday, October 22nd, 2018“…..The latest attack comes after two medical workers were killed by a militia in Eastern Congo Saturday while manning a port of entry to try to control the spread of Ebola. It’s believed to be the first time health workers have been killed by rebels in this Ebola outbreak……..”
With 11 new Ebola cases confirmed yesterday and today, the Democratic Republic of Congo’s Ebola outbreak total climbed to 205 cases
Saturday, October 13th, 2018Ebola virus disease – Democratic Republic of the Congo
The response to the Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo is becoming increasingly undermined by security challenges in at-risk areas, particularly Beni. These incidents severely impact both civilians and frontline workers, forcing suspension of EVD response activities and increasing the risk that the virus will continue to spread. WHO continues to distinguish between the incidents of conflict between rebel and government forces, and pockets of community push-back on the response. A recent increase in the incidence of new cases (Figure 1) is the result of the multitude of challenges faced by response teams. This also reflects improved active surveillance and reporting from the community.
Since the last Disease Outbreak News (data as of 2 October), 29 new confirmed EVD cases were reported: 23 from Beni, four from Butembo, one from Mabalako, and one from Masereka Health Zones in North Kivu Province. Fifteen of these confirmed cases have been linked to known cases or were linked retrospectively through case to transmission chains within the respective communities, while fourteen recently reported cases remain under investigation.
As of 9 October 2018, a total of 194 EVD cases (159 confirmed and 35 probable), including 122 deaths (87 confirmed and 35 probable)1, have been reported in seven health zones in North Kivu Province (Beni, Butembo, Kalunguta, Mabalako, Masereka, Musienene and Oicha), and three health zones in Ituri Province (Mandima, Komanda and Tchomia) (Figure 1). An overall increasing trend in weekly case incidence is seen (Figure 2); however, these rising trends are likely underestimated given expected delays in case reporting, the ongoing detection of sporadic cases, and security concerns which limit contact tracing and investigation of alerts. Of the 194 confirmed and probable cases for whom age and sex information is known, the majority (64%) are within 15-44 years age range. Females (55%) accounted for a greater proportion of cases (Figure 3). Since the last Disease Outbreak News update, one new health care worker infection was reported, bringing the cumulative case count to 20 (19 confirmed and one probable), of whom three have died.
The MoH, WHO and partners continue to closely monitor and investigate all alerts in affected areas, in other provinces in the Democratic Republic of the Congo, and in neighbouring countries. As of 9 October, 25 suspected cases in the Democratic Republic of the Congo are awaiting laboratory testing. Since 4 October, alerts have been investigated in several provinces of the Democratic Republic of the Congo, as well as in neighbouring countries. To date, EVD has been ruled out in all alerts from neighbouring provinces and countries.
Figure 1: Confirmed and probable Ebola virus disease cases by health zone in North Kivu and Ituri provinces, Democratic Republic of the Congo, data as of 9 October 2018 (n=194)
A significant increase in the number of new Ebola cases in DRC: “…. In just nine days, there have been 33 new cases and 15 deaths….”
Friday, October 12th, 2018“…..a World Health Organization (WHO) official says the epidemic will likely carry well into 2019.….”
Ebola: The situation in DRC is precarious given recent increases in insecurity, incidents of community reluctance and geographical spread.
Monday, October 1st, 2018Ebola virus disease – Democratic Republic of the Congo
The response to the Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo is at a critical juncture. While substantial progress has been made, the situation is precarious given recent increases in insecurity, incidents of community reluctance and geographical spread.
There have been a number of incidents in recent days, notably in Beni, which have led to loss of life among the local communities. WHO response activities have been severely limited as Beni and other towns mark a period of mourning for those who were killed. Security in Beni and other areas remains challenging.
The Ministry of Health (MoH), WHO and partners continue to work closely with people in the affected areas to overcome reluctance and mistrust which has developed among some communities. Rumours, misinformation and traditional practices have led some families to opt to care for sick relatives at home; some patients have also left health facilities to seek alternative care. Together this results in health workers being unable to provide optimal treatment, and also increases the risk of infection for relatives and local community members. These factors have contributed to the geographical spread of the outbreak.
The movement of several cases across health zones in recent weeks is concerning; one infected individual who recently moved to Kalunguta Health Zone is the first to move into a ‘red’ zone – highly insecure and challenging environments where implementing response activities is extremely difficult, if not impossible. Responders are employing a range of new techniques in these red zones, including using armed escorts and training local health workers to trace contacts.
Where they have access, response teams continue to enhance activities to prevent new clusters and the potential spread to new areas. WHO continues to work in the affected areas, side-by-side with national and international partners, to support the response led by the MoH. There continues to be challenges with identifying all contacts, registered contacts being lost to follow up, delayed recognition of EVD in health centres, poor infection prevention and control (IPC) in health centres, and reluctance among some cases to be treated in Ebola treatment centres (ETCs). The priority remains strengthening all components of the public health response in all affected areas, as well as continuing to enhance operational readiness and preparedness in the non-affected provinces of the Democratic Republic of the Congo and in neighbouring countries.
Since the last Disease Outbreak News (data as of 18 September), nine new confirmed EVD cases were reported: five from Beni, one from Butembo and one from Mabalako health zones in North Kivu Province, as well as two from Tchomia Health Zone in Ituri Province. These are the first confirmed EVD cases to be reported from Tchomia Health Zone which is near the Ugandan border; both cases, a couple, were linked to the ongoing Beni transmission chain. Two of the remaining seven cases have been linked to ongoing transmission chains within the respective communities, while the last five cases are under investigation.
As of 25 September 2018, a total of 151 EVD cases (120 confirmed and 31 probable), including 101 deaths (70 confirmed and 31 probable)1, have been reported in seven health zones in North Kivu Province (Beni, Butembo, Kalunguta, Mabalako, Masereka, Musienene and Oicha), and two health zones in Ituri Province (Mandima and Tchomia) (Figure 1). An overall decreasing trend in weekly case incidence continues (Figure 2); however, these trends must be interpreted with caution given the expected delays in case reporting, the ongoing detection of sporadic cases and the security situation which is limiting contact tracing. Of the 149 confirmed and probable cases for whom age and sex information is known, 23%, 20% and 22% are aged 15-24, 25-34 and 35-44 years, respectively; females (56%) accounted for the greatest proportion of cases (Figure 3). Cumulatively, 19 (18 confirmed and one probable) health workers have been affected to date, three of whom have died.
The MoH, WHO and partners continue to closely monitor and investigate all alerts in affected areas, in other provinces in the Democratic Republic of the Congo and in neighbouring countries. As of 25 September, 17 suspected cases in the Democratic Republic of the Congo are awaiting laboratory testing. Since the last report was published, alerts were investigated in several provinces of the Democratic Republic of the Congo, as well as in neighbouring countries; and to date, EVD has been ruled out in all alerts from neighbouring provinces and countries.
Figure 1: Confirmed and probable Ebola virus disease cases by health zone in North Kivu and Ituri provinces, Democratic Republic of the Congo, data as of 25 September 2018 (n=151)
DRC: 150 confirmed and suspected cases of Ebola, with 9 cases under investigation and the death toll stands at 100
Wednesday, September 26th, 2018“…..According to the WHO, 39 patients during this outbreak have been treated with experimental Ebola therapies, including mAb 114, remdesivir, and Zmapp. Of these 39 patients, 12 have died.
The DRC said that since immunization campaigns began on Aug 8, 11,563 people have been vaccinated….”
Sep 25 WHO media briefing:
DRC: Ebola in three more people
Sunday, September 16th, 2018Ebola virus disease – Democratic Republic of the Congo
Six weeks into the Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo, the overall situation has improved since the height of the epidemic; however, significant risks remain surrounding the continued detections of sporadic cases within Mabalako, Beni and Butembo health zones in North Kivu Province. While the majority of communities have welcomed response measures, such as daily contact monitoring and vaccination where appropriate, in some, risks of transmission and poor disease outcomes have been amplified by unfavourable behaviours, with reluctance to adopt prevention and risk mitigation behaviours. There have been challenges with contact tracing activities due to the constant movement of people between health zones, individuals hiding when symptoms develop and reports of community resistance. Risks are heightened by continued transmission in local health facilities because of poor infection prevention and control (IPC) measures, sporadic reports of unsafe burials, and the detection of cases in hard-to-reach and insecure areas.
Since the last Disease Outbreak News (data as of 5 September), eight new EVD cases, all of which are confirmed, have been reported: three from Beni, three from Butembo and two from Mabalako health zones. All eight new cases have been directly linked to an, ongoing transmission chain stemming from a community in Beni.
Of the three new cases in Butembo, one was an adult male from Mangina who reported an earlier illness and then was laboratory confirmed post-recovery via testing of a semen sample when his spouse was diagnosed with EVD. Given that he was asymptomatic since travelling to Butembo, the risk of onward transmission from this individual is minimal. The other two cases were health workers who cared for a subsequently-confirmed case (reported in the last Disease Outbreak News) at a small health post and assisted in her transfer to a tertiary hospital. This brings the total to 19 reported cases among health workers: 18 were laboratory confirmed and three have died. All 19 exposures occurred in local health facilities outside of dedicated Ebola treatment centres (ETCs).
As of 12 September 2018, a total of 137 EVD cases (106 confirmed and 31 probable), including 92 deaths (61 confirmed and 31 probable)1 have been reported in seven health zones in North Kivu Province (Beni, Butembo, Kalunguta, Mabalako, Masereka, Musienene and Oicha), and Mandima Health Zone in Ituri Province (Figure 1). An overall decreasing trend in weekly case incidence continues (Figure 2); however, these trends must be interpreted with caution given the expected delays in case reporting and the ongoing detection of sporadic cases. Of the 130 probable and confirmed cases for whom age and sex information is known, adults aged 35–44 years (22%) and females (57%) accounted for the greatest proportion of cases (Figure 3).
Alerts for suspected viral haemorrhagic fever cases in the outbreak-affected areas, other provinces of the Democratic Republic of the Congo, and in neighbouring countries continue to be closely monitored and rapidly investigated. In the outbreak-affected areas, 15–31 new alerts were reported each day during the past week, of which 4–16 alerts were verified as new suspected cases requiring further investigation and testing. As of 12 September, 17 suspected cases are currently pending testing to confirm or exclude EVD. Moreover, EVD was ruled out for recent alerts from Kasaji, Tanganyika, Tshopo and Kinshasa provinces, as well as for all alerts from neighbouring countries.
Figure 1: Confirmed and probable Ebola virus disease cases by health zone in North Kivu and Ituri provinces, Democratic Republic of the Congo, data as of 12 September 2018 (n=137)
Figure 2: Confirmed and probable Ebola virus disease cases by week of illness onset, data as of 12 September 2018 (n=137)*