UT College of Pharmacy and Pharmaceutical Sciences News

Posts Tagged ‘Amit Tiwari’

Dr. Tiwari’s Komen grant to find a cure for triple-negative breast cancer

Dr. Tiwari, assistant professor in the College of Pharmacy and Pharmaceutical Sciences Department of Pharmacology and Experimental Therapeutics, received a Komen grant for his research on drug-resistant triple-negative breast cancer, one of the most aggressive and difficult to treat cancers.

Click image below to see video from WTOL’s broadcast.

 


Collaborating for a Cure

Dr. Tiwari; Mary Kay Verhoff, director of the Women’s Wellness Center and Breast Cancer Coalition Awareness coordinator for St. Rita’s Medical Center, in Lima Ohio; and Angelique Nyinawabera, graduate student in Department of Pharmacology and Experimental Therapeutics.

Dr. Tiwari, Mary Kay Verhoff, director of the Women’s Wellness Center and Breast Cancer Coalition Awareness coordinator for St. Rita’s Medical Center, in Lima Ohio, and Angelique Nyinawabera

Dr. Amit K. Tiwari, assistant professor in the Department of Pharmacology and Experimental Therapeutics, was invited to present at the First Annual Breast Cancer Summit at St. Rita’s Medical Center in Lima, Ohio. The purpose of the summit was to improve breast cancer outcomes through early detection, survivorship support and health promotion, and participants included breast cancer survivors, primary health care personnel like nurses, technicians, physicians and pharmacists, and students and community members.

Triple-negative breast cancer (TNBC), which lacks three key cell surface receptors (ER,PR and HER2), is highly heterogeneous, aggressive, invasive, and metastatic. It recurs more frequently and offers a worse prognosis than other forms of breast cancer. TNBC also presents the highest health disparity, since it is three times more common among African-American women than among Caucasian women. Current chemotherapy, including targeted therapies, has limited value in the treatment of TNBC.

Dr. Tiwari discussed and provided information on current therapy options (taxanes, anthracyclines, PARP, platinums and other combinations) and future individualized therapy options for TNBC.

Angelique Nyinawabera, a graduate student in Department of Pharmacology and Experimental Therapeutics who is mentored by Dr. Tiwari, also attended the conference. Angelique’s research efforts are dedicated towards bridging the health disparity gap experienced by African-American women. Her dissertation focuses on targeting highly dysregulated mitochondrial genes to develop novel TNBC therapeutics.

This summit, which was designated for a maximum of 2.5 AMA PRA Category 1 Credits™, was sponsored by St. Rita’s Center for Continuing Education, which is accredited by the Ohio State Medical Association to provide continuing medical education for physicians. Dr. Tiwari believes this summit, and other similar programs that promote collaboration and discussion among patients, researchers and health care professionals, can improve care and outcomes tremendously, leading us toward a cure.


One Step Closer to a Cure

arantesVandressa Arantes, as part of the Brazilian Scientific Mobility Program, completed her summer research internship in Dr. Tiwari’s Cancer Chemotherapy Laboratory in the Department of Pharmacology and Experimental Therapeutics. Vandressa was a part of drug-discovery team in Dr. Tiwari’s lab. The team evaluates the anticancer activity of a novel class of targeted tyrosine kinase inhibitors (TKIs) belonging to the quinazoline class. Their target-based approach focuses on compounds that are designed and synthesized to work against ‘resistant’ solid tumors. These TKIs are designed ensure maximum effects of chemotherapy with minimal side-effects.

Vandressa spent her summer looking at the effects of a series of novel compounds on a panel of resistant and metastatic breast, colorectal and prostate cancer cell lines and comparing their effects to their normal counterparts.

To learn more about Dr. Tiwari’s work, visit his faculty web page. His lab is looking for undergraduate students who are interested in conducting research on these exciting anti-cancer drugs.


April 2015 Refill e-newsletter

The April 2015 issue of Refill, the e-newsletter of The University of Toledo College of Pharmacy and Pharmaceutical Sciences, is now available online.

In this issue:

  • RADM Helena Mishoe to receive honorary doctorate
  • Visit from Steven W. Schierholt, Esq., Executive Director of the Ohio State Board of Pharmacy
  • Patient education saves a life by Hanin Chouman
  • Alumnus Alex Adams, PharmD ’09, receives national leadership award
  • Alice H. Skeens Award for Dr. Amanda Bryant-Friedrich
  • Alumna Alison Wery, BSPS ’14, embarks on a career in cosmetic formulation
  • Student awards and presentations
  • OPA Student Legislative Day
  • Meet Dr. Amit K. Tiwari and Angela Lopez, M.Ed.
  • Thank you to donors
  • Calendar of events