Global & Disaster Medicine

CHIKV is a significant cause of CNS disease

Neurology

**  Between September 2005 and June 2006, 57 patients were diagnosed with CHIKV-associated CNS disease, including 24 with CHIKV-associated encephalitis, the latter corresponding to a CIR (cumulative incidence rate ) of 8.6 per 100,000 persons.

**  Patients with encephalitis were observed at both extremes of age categories.

**  187/100 000 (cumulative incidence rate ) in patients under 1 year of age

**  37/100 000 (cumulative incidence rate ) in patients over 65 years of age

**  The case-fatality rate of CHIKV-associated encephalitis was 16.6%

**  The proportion of children discharged with persistent disabilities estimated between 30% and 45%.

**  Beyond the neonatal period, the clinical presentation and outcomes were less severe in infants than in adults.


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