Global & Disaster Medicine

Archive for the ‘Ebola’ Category

WHO: In the past week, from 28 October to 3 November 2019, 10 new confirmed Ebola virus disease (EVD) cases were reported from five health zones in two affected provinces in the Democratic Republic of the Congo.

WHO

“…….As of 3 November 2019, a total of 3274 EVD cases were reported, including 3157 confirmed and 117 probable cases, of which 2185 cases died (overall case fatality ratio 67%). Of the total confirmed and probable cases, 56% (1843) were female, 28% (927) were children aged less than 18 years, and 5% (163) were healthcare workers. ……..”


Two potential drugs have shown a survival rate of as much as 90% in a clinical trial in the Democratic Republic of Congo (DRC).

The Sun

“…..The experimental treatments – REGN-EB3 and a monoclonal antibody called mAb114 – were both developed using antibodies from Ebola survivors.

They are now going to be offered to all patients in the DRC, according to US National Institute of Allergy and Infectious Diseases…..”

Medscape

“……The European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended approval of the V920 Ebola Zaire vaccine (Ervebo, Merck ), the first vaccine to protect against the Ebola virus disease caused by Zaire Ebola virus in at-risk adults aged 18 years or older…..”


WHO: Disease outbreak news Ebola virus disease – Democratic Republic of the Congo Disease outbreak news: Update 17 October 2019 The number of confirmed cases of Ebola virus disease (EVD) has been relatively low in recent weeks, with 15 new confirmed cases

WHO

“……As of Tuesday, there have been 3,227 confirmed or probable cases and 2,154 deaths since the outbreak began in August 2018, so the fatality rate is still high at 67 percent, despite the rollout of two highly effective treatments.

The treatments — infusions of antibodies — work only if they are given soon after a patient is infected…….”


Three new Ebola cases confirmed, raising total to 3,178

“The steady trickle of new Ebola cases in the Democratic Republic of the Congo (DRC) continued today, with the World Health Organization (WHO) dashboard showing three new cases and three new fatalities.

The outbreak total now stands at 3,178 cases, with 2,122 deaths, and 520 suspected cases under investigation…..”

WHO Ebola dashboard


The WHO is getting nervous about Ebola in Tanzania and no one notifying them about it.

WHO

“……On 10 September 2019, through its regular event-based surveillance process, WHO was made aware of unofficial reports regarding the death of a person with suspected Ebola Virus disease (EVD) case in Dar es Salaam, United Republic of Tanzania. The identified contacts of the deceased were unofficially reported to be quarantined in various sites in the country. Under the IHR Articles 9 and 10, WHO immediately sent a verification request to the National IHR Focal Point (NFP) of the country.

On 11 September, through its regular event-based surveillance process, WHO was made aware of unofficial reports that a RT-PCR test performed at the Tanzanian National Health Laboratory was positive for EVD for this patient. On the same day, WHO received unofficial reports regarding another suspected EVD case in Mwanza, located in the northern region of the United Republic of Tanzania, who later tested negative for EVD. WHO continued to reach out under the IHR to the health authorities of the United Republic of Tanzania to verify these signals.

On 12 September 2019, WHO was informed by unofficial sources of a 27-year-old patient suspected of EVD admitted in a hospital of Dar es Salaam without further information regarding laboratory tests and results

Despite several requests, WHO did not receive further details of any of these cases from Tanzanian authorities…..”


Ebola virus disease – Democratic Republic of the Congo Disease outbreak news: Update (12 September 2019)

“……As of 10 September, a total of 3091 EVD cases were reported, including 2980 confirmed and 111 probable cases, of which 2074 cases died (overall case fatality ratio 67%). Of the total confirmed and probable cases, 56% (1737) were female, 29% (886) were children aged less than 18 years, and 5% (157) were health workers…….”

 


Subsequent mortality in survivors of Ebola virus disease in Guinea: a nationwide retrospective cohort study

Subsequent mortality in survivors of Ebola virus disease in Guinea: a nationwide retrospective cohort study

Published:September 04, 2019DOI:https://doi.org/10.1016/S1473-3099(19)30313-5

“Findings

….Of the 1270 survivors of Ebola virus disease who were discharged from Ebola treatment units in Guinea, information was retrieved for 1130 (89%). Compared with the general Guinean population, survivors of Ebola virus disease had a more than five-times increased risk of mortality up to Dec 31, 2015 (age-standardised mortality ratio 5·2 [95% CI 4·0–6·8]), a mean of 1 year of follow-up after discharge. Thereafter (ie, from Jan 1–Sept 30, 2016), mortality did not differ between survivors of Ebola virus disease and the general population. (0·6 [95% CI 0·2–1·4]). Overall, 59 deaths were reported, and the cause of death was tentatively attributed to renal failure in 37 cases, mostly on the basis of reported anuria. Longer stays (ie, equal to or longer than the median stay) in Ebola treatment units were associated with an increased risk of late death compared with shorter stays (adjusted hazard ratio 2·62 [95% CI 1·43–4·79]).

Interpretation

Mortality was high in people who recovered from Ebola virus disease and were discharged from Ebola treatment units in Guinea. The finding that survivors who were hospitalised for longer during primary infection had an increased risk of death, could help to guide current and future survivors’ programmes and in the prioritisation of funds in resource-constrained settings. The role of renal failure in late deaths after recovery from Ebola virus disease should be investigated….”

WHO: 5 new confirmed cases of Ebola, raising the outbreak total to 3,054, with 444 suspected cases under investigation plus there were also 5 additional deaths noted, raising the fatality total to 2,050.

WHO

 

 


WHO: 10 new cases of Ebola have been confirmed in the Democratic Republic of the Congo (DRC), raising the outbreak total to 2,852, and 380 suspected cases are still under investigation.

WHO


A trial of two Ebola drugs showed significantly improved survival rates

BBC

“……Four drugs were trialled on patients in the Democratic Republic of Congo, where there is a major outbreak of the virus.

More than 90% of infected people can survive if treated early with the most effective drugs…….”


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