Archive for the ‘Neglected Tropical Diseases’ Category
Drugs for Neglected Diseases initiative (DNDi): A collaborative, patients’ needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for neglected diseases.Wednesday, February 22nd, 2017
Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients’ needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for neglected patients.
DNDi is working on the following diseases:
- Sleeping Sickness (human African trypanosomiasis)
- Chagas disease
- Paediatric HIV
- Filarial diseases
- Hepatitis C
In 2015, DNDi handed over its Malaria portfolio.
Working in partnership with private industry, public institutions, academia and NGOs, DNDi has built the largest ever R&D portfolio for kinetoplastid diseases.
To date, DNDi has successfully delivered, recommended and implemented:
- Two new fixed-dose combinations for Malaria (2007 & 2008) – ASAQ, ASMQ
- Better simpler treatment against Sleeping Sickness (2009) – NECT
- Cheaper more effective treatment in Africa against Visceral Leishmaniasis (VL) (2010) – SSG&PM
- A set of treatments in South Asia for VL (2011)
- A paediatric form of benznidazole for Chagas disease (2011)
- More effective treatment for children who are co-infected with HIV and TB (2016) – Superbooster Therapy
“…Yet one of the most inspiring success stories is perhaps the one most overlooked: the global effort to eliminate neglected tropical diseases, or NTDs.
Much of the recent success stems from a meeting in London on Jan. 30, 2012 ……
NTDs affect nearly 1.5 billion of the poorest and most marginalized people around the world. And while 500,000 people lose their lives to NTDs every year, these diseases are more likely to disable and disfigure than to kill. …….These agonizing conditions keep children from school and adults from work, trapping families and communities in cycles of poverty……
Today, the landscape is dramatically different. In 2015, nearly 1 billion people received NTD treatments — 20 percent more than just two years before. As a result, fewer people are suffering from these diseases than at any point in history. ……Much of this success can be traced to the 2012 meeting in London. There, the World Health Organization, pharmaceutical companies, donors, governments, and non-governmental organizations committed to work together to control and eliminate 10 NTDs. …”
THE LONDON DECLARATION
For decades, partners including pharmaceutical companies, donors, endemic countries and non-government organisations have contributed technical knowledge, drugs, research, funding and other resources to treat and prevent Neglected Tropical Diseases (NTDs) among the world’s poorest populations. Great progress has been made, and we are committed to build on these efforts.
Inspired by the World Health Organization’s 2020 Roadmap on NTDs, we believe there is a tremendous opportunity to control or eliminate at least 10 of these devastating diseases by the end of the decade. But no one company, organization or government can do it alone. With the right commitment, coordination and collaboration, the public and private sectors will work together to enable the more than a billion people suffering from NTDs to lead healthier and more productive lives-helping the world’s poorest build self-sufficiency. As partners, with our varied skills and contributions, we commit to doing our part to:
We commit to doing our part to:
- Sustain, expand and extend programmes that ensure the necessary supply of drugs and other interventions to help eradicate Guinea worm disease, and help eliminate by 2020 lymphatic filariasis, leprosy, sleeping sickness (human African trypanosomiasis) and blinding trachoma.
- Sustain, expand and extend drug access programmes to ensure the necessary supply of drugs and other interventions to help control by 2020 schistosomiasis, soil-transmitted helminthes, Chagas disease, visceral leishmaniasis and river blindness (onchocerciasis).
- Advance R&D through partnerships and provision of funding to find next-generation treatments and interventions for neglected diseases.
- Enhance collaboration and coordination on NTDs at national and international levels through public and private multilateral organisations.
- Enable adequate funding with endemic countries to implement NTD programmes necessary to achieve these goals, supported by strong and committed health systems at the national level.
- Provide technical support, tools and resources to support NTD-endemic countries to evaluate and monitor programmes.
- Provide regular updates on the progress in reaching the 2020 goals and identify remaining gaps.
To achieve this ambitious 2020 vision, we call on all endemic countries and the international; community to join us in the above commitments to provide the resources necessary across sectors to remove the primary risk factors for NTDs-poverty and exposure-by ensuring access to clean water and basic sanitation, improved living conditions, vector control, health and education, and stronger health systems in endemic areas.
We believe that, working together, we can meet our goals by 2020 and chart a new course toward health and sustainability among the world’s poorest communities to a stronger, healthier future.