Thrombocytopenia and subcutaneous bleedings in a patient with Zika virus infection
February 23rd, 2016Thrombocytopenia and subcutaneous bleedings in a patient with Zika virus infection
Published online: February 19, 2016
Ouafae Karimi, Abraham Goorhuis, Janke Schinkel, John Codrington, Stephen Gerold S Vreden, Joost S Vermaat, Cornelis Stijnis, Martin Peter Grobusch
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)00502-X/abstract
“…. we report a patient with Zika virus infection that was related to clinically relevant thrombocytopenia and subcutaneous haematomas…….Laboratory examination showed slight microcytic anaemia (haemoglobin concentration 7·2 mmol/L) but a normal haematocrit, and a profound thrombocytopenia of 20 × 10⁹ platelets per L, with normal coagulation parameters. A watch-and wait decision was made. On day 29, she developed gum bleeding, at a thrombocyte count of 10 × 10⁹ platelets per L. At this point, we decided to treat her presumed immune-mediated thrombocytopenia with intravenous immunoglobulins, upon which her thrombocyte count increased to 80 × 10⁹ platelets per L within a few days. …….”