University of Texas Medical Branch at Galveston have developed 3 new possible vaccines against the plague.
January 14th, 2017Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague; Bethany L Tiner, Jian Sha, Yingzi Cong, et al. Vaccines 1, Article number: 16020 (2016); doi:10.1038/npjvaccines.2016.20
“…It is crucial that a potential vaccine candidate(s) demonstrates long-term immune responses and protection. This is the first study to examine several components of the immune response generated after immunisation of mice and rats with the above three live-attenuated mutants over a period of 3–4 months……Overall, all three live-attenuated mutants stimulated long-lasting T cell-mediated immune responses capable of protecting mice from developing subsequent pneumonic plague….Most importantly, all three live-attenuated mutants stimulated both long-term humoral- and cell-mediated immune responses, which protected mice against exposure to highly lethal pneumonic challenge….”