Global & Disaster Medicine

What is Interferon and what does it have to do with the flu?

January 22nd, 2018

Interferon “….(IFN) expression is a mammal’s first response to viral infection. Many viruses have thus evolved mechanisms to evade IFN. Du et al. developed a method to systematically ablate IFN evasion genes from live, attenuated influenza virus…. A combination of mutants was assembled to construct a virus that triggered transient IFN responses in mice but that was unable to replicate effectively. The transient IFN responses led to robust antibody and memory responses that protected against subsequent challenge with different influenza viruses. This approach could be adapted to improve other RNA virus vaccines.

This entry was posted on Monday, January 22nd, 2018 at 10:38 am and is filed under Influenza .
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