Global & Disaster Medicine

Archive for May, 2018

WHO: List of Blueprint priority diseases (i.e. diseases and pathogens to prioritize for research and development in public health emergency contexts)

WHO

2018 annual review of the Blueprint list of priority diseases

For the purposes of the R&D Blueprint, WHO has developed a special tool for determining which diseases and pathogens to prioritize for research and development in public health emergency contexts. This tool seeks to identify those diseases that pose a public health risk because of their epidemic potential and for which there are no, or insufficient, countermeasures. The diseases identified through this process are the focus of the work of R& D Blueprint. This is not an exhaustive list, nor does it indicate the most likely causes of the next epidemic.

The first list of prioritized diseases was released in December 2015.

Using a published prioritization methodology, the list was first reviewed in January 2017.

February 2018 – Second annual review

The second annual review occurred 6-7 February, 2018. Experts consider that given their potential to cause a public health emergency and the absence of efficacious drugs and/or vaccines, there is an urgent need for accelerated research and development for*:

  • Crimean-Congo haemorrhagic fever (CCHF)
  • Ebola virus disease and Marburg virus disease
  • Lassa fever
  • Middle East respiratory syndrome coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS)
  • Nipah and henipaviral diseases
  • Rift Valley fever (RVF)
  • Zika
  • Disease X

Disease X represents the knowledge that a serious international epidemic could be caused by a pathogen currently unknown to cause human disease, and so the R&D Blueprint explicitly seeks to enable cross-cutting R&D preparedness that is also relevant for an unknown “Disease X” as far as possible.

A number of additional diseases were discussed and considered for inclusion in the priority list, including: Arenaviral hemorrhagic fevers other than Lassa Fever; Chikungunya; highly pathogenic coronaviral diseases other than MERS and SARS; emergent non-polio enteroviruses (including EV71, D68); and Severe Fever with Thrombocytopenia Syndrome (SFTS).

These diseases pose major public health risks and further research and development is needed, including surveillance and diagnostics. They should be watched carefully and considered again at the next annual review. Efforts in the interim to understand and mitigate them are encouraged.

Although not included on the list of diseases to be considered at the meeting, monkeypox and leptospirosis were discussed and experts stressed the risks they pose to public health. There was agreement on the need for: rapid evaluation of available potential countermeasures; the establishment of more comprehensive surveillance and diagnostics; and accelerated research and development and public health action.

Several diseases were determined to be outside of the current scope of the Blueprint: dengue, yellow fever, HIV/AIDs, tuberculosis, malaria, influenza causing severe human disease, smallpox, cholera, leishmaniasis, West Nile Virus and plague. These diseases continue to pose major public health problems and further research and development is needed through existing major disease control initiatives, extensive R&D pipelines, existing funding streams, or established regulatory pathways for improved interventions. In particular, experts recognized the need for improved diagnostics and vaccines for pneumonic plague and additional support for more effective therapeutics against leishmaniasis.

The experts also noted that:

  • For many of the diseases discussed, as well as many other diseases with the potential to cause a public health emergency, there is a need for better diagnostics.
  • Existing drugs and vaccines need further improvement for several of the diseases considered but not included in the priority list.
  • Any type of pathogen could be prioritised under the Blueprint, not only viruses.
  • Necessary research includes basic/fundamental and characterization research as well as epidemiological, entomological or multidisciplinary studies, or further elucidation of transmission routes, as well as social science research.
  • There is a need to assess the value, where possible, of developing countermeasures for multiple diseases or for families of pathogens.

The impact of environmental issues on diseases with the potential to cause public health emergencies was discussed. This may need to be considered as part of future reviews.

The importance of the diseases discussed was considered for special populations, such as refugees, internally displaced populations, and victims of disasters.

The value of a One Health approach was stressed, including a parallel prioritization processes for animal health. Such an effort would support research and development to prevent and control animal diseases minimising spill-over and enhancing food security. The possible utility of animal vaccines for preventing public health emergencies was also noted.

Also there are concerted efforts to address anti-microbial resistance through specific international initiatives. The possibility was not excluded that, in the future, a resistant pathogen might emerge and appropriately be prioritized.

 

*The order of diseases on this list does not denote any ranking of priority.

 


Kilauea: New eruptions & 1 person injured


Sex trafficking in Nepal

Diplomat

“…..12,000 to 15,000 girls each year are trafficked from Nepal across the border where they are sold into Indian brothels and forced to become prostitutes…..UNICEF reports that as many as 7,000 women and girls are trafficked out of Nepal to India every year, and around 200,000 are now working in Indian brothels………”

 


Volcanic ashfall in American history


Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE)

 

SUPPLEMENT ARTICLES

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S1–S5, https://doi.org/10.1093/infdis/jix665

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S6–S15, https://doi.org/10.1093/infdis/jiy020

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S16–S23, https://doi.org/10.1093/infdis/jix657

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S24–S32, https://doi.org/10.1093/infdis/jiy042

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S33–S39, https://doi.org/10.1093/infdis/jiy061

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S40–S47, https://doi.org/10.1093/infdis/jix558

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S48–S55, https://doi.org/10.1093/infdis/jix336

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S56–S59, https://doi.org/10.1093/infdis/jiy111

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S60–S64, https://doi.org/10.1093/infdis/jix389

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S65–S74, https://doi.org/10.1093/infdis/jiy094

The Journal of Infectious Diseases, Volume 217, Issue suppl_1, 18 May 2018, Pages S75–S80, https://doi.org/10.1093/infdis/jix603

Statement on the 1st meeting of the IHR Emergency Committee regarding the Ebola outbreak in 2018

WHO

18 May 2018

Statement

The 1st meeting of the Emergency Committee convened by the WHO Director-General under the International Health Regulations (IHR) (2005) regarding the Ebola Virus Disease (EVD) outbreak in the Democratic Republic of the Congo took place on Friday 18 May 2018, from 11:00 to 14:00 Geneva time (CET).

Emergency Committee conclusion

It was the view of the Committee that the conditions for a Public Health Emergency of International Concern (PHEIC) have not currently been met.

Meeting

Members and advisors of the Emergency Committee met by teleconference. Presentations were made by representatives of the Democratic Republic of the Congo on recent developments, including measures taken to implement rapid control strategies, and existing gaps and challenges in the outbreak response. During the informational session, the WHO Secretariat provided an update on and assessment of the Ebola outbreak.

The Committee’s role was to provide to the Director-General their views and perspectives on:

  • Whether the event constitutes a Public Health Emergency of International Concern (PHEIC)
  • If the event constitutes a PHEIC, what Temporary Recommendations should be made

Current situation

On 8 May, WHO was notified by the Ministry of Health of the Democratic Republic of the Congo of two lab-confirmed cases of Ebola Virus Disease occurring in Bikoro health zone, Equateur province. Cases have now also been found in nearby Iboko and Mbandaka. From 4 April to 17 May 2018, 45 EVD cases have been reported, including in three health care workers, and 25 deaths have been reported. Of these 45 cases, 14 have been confirmed. Most of these cases have been in the remote Bikoro health zone, although one confirmed case is in Mbandaka, a city of 1.2 million, which has implications for its spread.

Nine neighbouring countries, including Congo-Brazzaville and Central African Republic, have been advised that they are at high risk of spread and have been supported with equipment and personnel.

Key Challenges

After discussion and deliberation on the information provided, the Committee concluded these key challenges:

  • The Ebola outbreak in the Democratic Republic of the Congo has several characteristics that are of particular concern: the risk of more rapid spread given that Ebola has now spread to an urban area; that there are several outbreaks in remote and hard to reach areas; that health care staff have been infected, which may be a risk for further amplification.
  • The risk of international spread is particularly high since the city of Mbandaka is in proximity to the Congo river, which has significant regional traffic across porous borders.
  • There are huge logistical challenges given the poor infrastructure and remote location of most cases currently reported; these factors affect surveillance, case detection and confirmation, contact tracing, and access to vaccines and therapeutics.

However, the Committee also noted the following:

  • The response by the government of the Democratic Republic of the Congo, WHO and partners has been rapid and comprehensive.
  • Interventions underway provide strong reason to believe that the outbreak can be brought under control, including: enhanced surveillance, establishment of case management facilities, deployment of mobile laboratories, expanded engagement of community leaders, establishment of an airbridge, and other planned interventions.
  • In addition, the advanced preparations for use of the investigational vaccine provide further cause for optimism for control

In conclusion, the Emergency Committee, while noting that the conditions for a PHEIC are not currently met, issued Public Health Advice as follows:

  • Government of the Democratic Republic of the Congo, WHO, and partners remain engaged in a vigorous response – without this, the situation is likely to deteriorate significantly. This response should be supported by the entire international community.
  • Global solidarity among the scientific community is critical and international data should be shared freely and regularly.
  • It is particularly important there should be no international travel or trade restrictions.
  • Neighbouring countries should strengthen preparedness and surveillance.
  • During the response, safety and security of staff should be ensured, and protection of responders and national and international staff should prioritised.
  • Exit screening, including at airports and ports on the Congo river, is considered to be of great importance; however entry screening, particularly in distant airports, is not considered to be of any public health or cost-benefit value.
  • Robust risk communication (with real-time data), social mobilisation, and community engagement are needed for a well-coordinated response and so that those affected understand what protection measures are being recommended;
  • If the outbreak expands significantly, or if there is international spread,  the Emergency Committee will be reconvened.

The Committee emphasized the importance of continued support by WHO and other national and international partners towards the effective implementation and monitoring of this advice.

Based on this advice, the reports made by the affected States Parties, and the currently available information, the Director-General accepted the Committee’s assessment and on 18 May 2018 did not declare the Ebola outbreak in the Democratic Republic of the Congo a Public Health Emergency of International Concern (PHEIC). In light of the advice of the Emergency Committee, WHO advises against the application of any travel or trade restrictions. The Director-General thanked the Committee Members and Advisors for their advice.

 


May 18, 1980: Mt. St. Helens erupts; 60 killed

USGS

Prior to 1980, Mount St. Helens had the shape of a conical, youthful volcano sometimes referred to as the Mount Fuji of America. During the 1980 eruption the upper 400 m (1,300 ft) of the summit was removed by a huge debris avalanche, leaving a 2 x 3.5 km (1.2 x 2.2 mi) horseshoe-shaped crater now partially filled by a lava dome and a glacier. It is primarily an explosive dacite volcano with a complex magmatic system.

Mount St. Helens was formed during four eruptive stages beginning about 275,000 years ago and has been the most active volcano in the Cascade Range during the Holocene. Prior to about 12,800 years ago, tephra, lava domes, and pyroclastic flows were erupted, forming the older St. Helens edifice, but a few lava flows extended beyond the base of the volcano. The bulk of the modern edifice (above the 1980 crater floor) was constructed during the last 3,000 years, when the volcano erupted a wide variety of products from summit and flank vents. Historical eruptions in the 19th century originated from the Goat Rocks area on the north flank, and were witnessed by early settlers. New unpublished data on the timing for Mount St. Helens eruptive activity have been analyzed, which improves some of the eruption dates cited in published literature. This website contains the most up to date information.

Since its 1980 eruption, the summit elevation has decreased. A survey in 1982 gave a measurement of 2549.7 m (8365 ft). However, a lidar survey done in 2009 found the maximum elevation to be 2539 m (8330 ft). The difference in elevation is likely due to erosion and loss of rimrock by crater-wall collapses.

Digital Elevation Map of Mount St. Helens with annotation of pre-1980 topography and deposits from 1980 - 2008.


May 18, 1927: Bath School Disaster, Bath MI. Andrew Kehoe blows up Bath Consolidated School killing 38 children, 2 teachers.


An illegal u-turn? A school bus taking children on a field trip collided with a dump truck leaving at least 2 dead and sending 43 to hospitals.

EMS1

 


More than 100 people are feared dead after a Boeing 737 airliner crashed and burned after takeoff from Havana, Cuba.

NY Post


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