Global & Disaster Medicine

The 1918 Pandemic: Origin, pathology, and the virus itself

Unanswered questions about the 1918 influenza pandemic: origin, pathology, and the virus itself

Oxford, John S et al.
The Lancet Infectious Diseases, 2018

  • “…Studies of the resurrected 1918 virus showed it to be somewhat more virulent than contemporary H1N1 epidemic viruses in animal models, but not enough to be the sole factor in the high mortality rates…..”
  • “…A cytokine storm, together with previous immune history, were important factors in explaining both enhanced pathology and protection from death….”

 


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