Global & Disaster Medicine

A Dual Vaccine against Anthrax and Plague

December 5th, 2018
A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague
Pan Tao, Marthandan Mahalingam, Jingen Zhu, Mahtab Moayeri, Jian Sha, William S. Lawrence, Stephen H. Leppla, Ashok K. Chopra, Venigalla B. Rao
mBio Oct 2018, 9 (5) e01926-18; DOI: 10.1128/mBio.01926-18
“…..We engineered a virus nanoparticle vaccine using bacteriophage T4 by incorporating key antigens of both B. anthracis and Y. pestis into one formulation. Two doses of this vaccine provided complete protection against both inhalational anthrax and pneumonic plague in animal models. This dual anthrax-plague vaccine is a strong candidate for stockpiling against a potential bioterror attack involving either one or both of these biothreat agents. Further, our results establish the T4 nanoparticle as a novel platform to develop multivalent vaccines against pathogens of high public health significance……”
Plague ecology in the U.S. infographic.
This entry was posted on Wednesday, December 5th, 2018 at 3:35 am and is filed under Anthrax, Plague .
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