CHIKV is a significant cause of CNS disease
November 30th, 2015** Between September 2005 and June 2006, 57 patients were diagnosed with CHIKV-associated CNS disease, including 24 with CHIKV-associated encephalitis, the latter corresponding to a CIR (cumulative incidence rate ) of 8.6 per 100,000 persons.
** Patients with encephalitis were observed at both extremes of age categories.
** 187/100 000 (cumulative incidence rate ) in patients under 1 year of age
** 37/100 000 (cumulative incidence rate ) in patients over 65 years of age
** The case-fatality rate of CHIKV-associated encephalitis was 16.6%
** The proportion of children discharged with persistent disabilities estimated between 30% and 45%.
** Beyond the neonatal period, the clinical presentation and outcomes were less severe in infants than in adults.