Global & Disaster Medicine

Study some ferrets inoculated intranasally with 1918 H1N1 virus and see what happens…..

January 11th, 2018

1918 Pandemic research article

1918 H1N1 influenza virus replicates and induces pro-inflammatory cytokine responses in extra-respiratory tissues of ferrets

Emmie de Wit
Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States of America
Emmie de Wit: 903 South 4th Street, Hamilton, MT 59840, USA; phone: +1-406-375-7490; fax: +1-406-375-9620; Emmie.deWit@nih.gov
“…..Evidence for active virus replication, as indicated by the detection of nucleoprotein by immunohistochemistry, was observed in the respiratory tract, peripheral and central nervous system, and liver. Pro-inflammatory cytokines were upregulated in respiratory tissues, olfactory bulb, spinal cord, liver, heart and pancreas…..”
Corresponding authors: Debby van Riel: P.O. Box 2040, Ee1716, 3000 CA Rotterdam, The Netherlands; phone +31 10 704 4069; fax: +31 10 704 4760; d.vanriel@erasmusmc.nl
The Journal of Infectious Diseases, jiy003, https://doi.org/10.1093/infdis/jiy003
This entry was posted on Thursday, January 11th, 2018 at 4:56 am and is filed under Documents, Pandemic .
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